Human bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any … See more The two isoforms of Bcl-2, Isoform 1, and Isoform 2, exhibit a similar fold. However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of … See more Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate See more Targeted and selective Bcl-2 inhibitors that have been in development or are currently in the clinic include: Oblimersen An antisense See more • Apoptosome • Bcl-2 homologous antagonist killer (BAK) • Bcl-2-associated X protein (BAX) • BH3 interacting domain death agonist (BID) See more BCL-2 is localized to the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and … See more Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. In healthy tissue, these antibodies react with B-cells in the mantle zone, … See more Bcl-2 has been shown to interact with: • BAK1, • BCAP31, • BCL2-like 1, • BCL2L11, See more http://antibodysystem.com/product/3200.html
Human bcl-2
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WebDec 4, 2024 · B-cell lymphoma 2 (BCL2) is a key protein regulator of apoptosis. It is variably highly expressed in many hematological malignancies, providing protection from cell … WebThese antibodies target BCL-2 in Human, Mouse, Rat, Bovine and Rabbit samples. Our BCL-2 polyclonal, monoclonal, recombinant monoclonal and recombinant polyclonal …
WebBcl-2. A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t (14;18) translocation results in a … WebBcl-2 è il prototipo di una famiglia di geni, e delle corrispondenti proteine codificate, presenti nei mammiferi. Queste proteine governano la permeabilità della membrana mitocondriale …
WebMay 27, 2024 · Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway. The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to … WebStore at 2 to 8 °C for one week . Store at -20 to -80 °C for twelve months from the date of receipt. Reconstitution. Reconstitute in sterile water for a stock solution. A copy of …
WebThe Bcl-2 family proteins consists of members that either promote or inhibit apoptosis, and control apoptosis by governing mitochondrial outer membrane permeabilization (MOMP), …
WebAnti-Bcl-2 antibody [E17] (ab32124) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant … ohio bwc refund 2020WebBcl-2 is an intracellular membrane protein and resides primarily in the nuclear envelope, outer mitochondrial membrane and endoplasmic reticulum. The reduced molecular … myhealth online account upmcWebThe anti-apoptotic B cell CLL/lymphoma-2 (Bcl-2) protein is a key player in the regulation of programmed cell death and is linked to various types of cancer and their resistance to … ohio bwc rebatesWebMay 31, 2001 · The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in … ohio bwc physician of recordWebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. ohio bwc policy searchWebApr 8, 2024 · Proteins from the BCL-2 family control cell survival and apoptosis in health and disease, and regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, … ohio bwc par programWebThe Human Bcl-2 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. … ohio bwc premium refund 2022