WebSep 9, 2005 · The R120G missense mutation in the small heat-shock protein α-B-crystallin (CryAB) causes desmin-related cardiomyopathy (DRM) ().DRM, which is characterized by the formation of aggregates containing CryAB and desmin, can be recapitulated in transgenic (TG) mice by expression of the mutant protein specifically in the heart ().We … WebSep 26, 2024 · chaperone alphaB-crystallin (CRYAB) is a MYOC-binding partner and that co-expression of these two proteins increases protein aggregates. Ectopic UAP56 …
WO/2024/014718 25-HYDROXYCHOLESTEROL (25HC), …
WebMar 29, 2024 · Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although … WebClinVar archives and aggregates information about relationships among variation and human health. ground pass tennis
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WebMay 30, 2024 · CRYAB is a member of the small heat shock protein family, first discovered in the lens of the eye, and involved in various diseases, such as eye and heart diseases … List of PDB id codes. 2KLR, 2N0K, 2WJ7, 2Y1Y, 2Y1Z, 2Y22, 2YGD, 3L1G, 3SGM, 3SGN, 3SGO, 3SGP, 3SGR, 3SGS, 4M5S, 4M5T, 3J07. Identifiers. Aliases. CRYAB, CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2, crystallin alpha B. External IDs. OMIM: 123590 MGI: 88516 HomoloGene: 68209 … See more Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent … See more Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of … See more Although not yet clearly understood, defective chaperone activity is expected to trigger the accumulation of protein aggregates and underlie the development of α-crystallinopathy, or the failure of protein quality control, resulting in protein deposition diseases … See more • Derham BK, Harding JJ (July 1999). "Alpha-crystallin as a molecular chaperone". Progress in Retinal and Eye Research. 18 (4): 463–509. doi:10.1016/S1350-9462(98)00030-5. PMID 10217480. S2CID 25124893. • Calinisan V, Gravem D, Chen … See more Alpha B chain crystallins (αBC) can be induced by heat shock, ischemia, and oxidation, and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and … See more CRYAB has been shown to interact with: • CRYAA, • CRYBB2, • CRYGC, • HSPB2, See more • GeneReviews/NIH/NCBI/UW entry on Myofibrillar Myopathy See more WebMar 21, 2024 · Alpha-crystallin B chains enhance cell migration in basal-like 2 triple-negative breast cancer cells. Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each … fill up boursorama