Biobank japan release of disease traits
WebNov 29, 2024 · in a curated set of human diseases and traits using a unique resource of 200,000 individuals with exome sequencing data from the UK Biobank. Methods and Results: We included 199,832 participants with a mean age of 68 at follow-up. Exome-wide gene-based tests were performed for 64 diseases and 23 quantitative traits using a … WebOct 25, 2024 · Researchers from Osaka University address inequities in genomic research by analyzing data for over 200 health-related traits and diseases in an Asian population …
Biobank japan release of disease traits
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WebApr 15, 2024 · Genome-wide association studies (GWAS) have identified tens of thousands of genetic loci associated with human complex traits and diseases[1][1],[2][2]. However, the majority of GWAS were conducted in individuals of European ancestry[3][3]. Failure to capture global genetic diversity has limited biological discovery and impeded equitable … Web18 hours ago · Abstract. Reproduction involves a wide range of biological processes, including organ formation and development, neuroendocrine regulation, hormone …
WebMar 21, 2024 · Growing evidence suggests that red meat consumption is a risk factor for cardiovascular health, with potential sex disparity. The metabolic mechanisms have not been fully understood. Using the UK Biobank, first we examined the associations of unprocessed red meat and processed meat with ischemic heart disease (IHD) mortality … WebApr 10, 2024 · INTRODUCTION. Obesity is a chronic disease and an independent risk factor for many major diseases [()].Over the past 30 years, the prevalence of overweight as well as general and central obesity has soared in both men and women globally and in China [(2-4)].Unhealthy dietary habits are a well-established risk factor for obesity …
WebApr 27, 2024 · A huge genetic study could lead to diagnostic tests customized to people in Japan. In one of the largest genetic studies ever to come out of Asia, RIKEN scientists … WebNational Center for Biotechnology Information
WebApr 15, 2024 · Findings from 102,900 individuals across 36 human quantitative traits in the Taiwan Biobank (TWB), a major biobank effort that broadens the population diversity of genetic studies in East Asia, are reported to facilitate within-EAS and cross-population genetic research. Genome-wide association studies (GWAS) have identified tens of …
WebBackground: We established a patient-oriented biobank, BioBank Japan, with information on approximately 200,000 patients, suffering from any of 47 common diseases. This follow … chittaway chemistWebDec 10, 2024 · UK Biobank is a major prospective epidemiological study that is carrying out detailed multimodal brain imaging on 100,000 participants, and includes genetics and ongoing health outcomes. As a step forwards in understanding genetic influence on brain structure and function, in 2024 we published genome-wide associations of 3,144 brain … chittaway bay tavernWebJun 16, 2024 · We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in UKB. We also release a benchmarking software tool to enable like-for-like performance evaluation for different PRSs for the same disease or trait. Extensive … chittaway healthsaveWebMar 29, 2024 · Lastly, we identified nine disease traits at least nominally significant in discovery and Bonferroni-significant in replication, categorized as tier 3 results. Several … chittaway colesWebJun 8, 2024 · The 42 diseases encompassed a wide range of disease categories: 13 neoplastic diseases, five cardiovascular diseases, four … grass-fed beef vs grain-fed beefWeb14 Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. [email protected]. 15 Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. [email protected]. chittaway floodingWebWe applied PolyPred + to 23 diseases/traits in UK Biobank east Asians using both UK Biobank British and Biobank Japan training data, and observed improvements of +24% versus BOLT-LMM and +12% versus PolyPred. Summary statistics-based analogs of PolyPred and PolyPred + attained similar improvements. chittaway chinese